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Express yourself freely with natural-looking Restylane Refyne and Defyne dermal fillers in Cleveland

Seriously Skin is pleased to offer two new products specially formulated to produce natural results that allow for utmost freedom of facial movement: Restylane Refyne and Defyne Dermal fillers in Cleveland.

Restylane: A family of fillers

Like its sister products, Restylane Refyne and Restylane Defyne are made from Hyaluronic Acid. When precisely injected under facial tissue in a targeted area, these fillers replace naturally-occurring HA responsible for youthful- and luminous-looking skin.
Restylane Refyne
Restylane Defyne

The unique benefits

These newest additions to the Restylane family are FDA-approved to correct moderate to severe wrinkles and folds around the nose and mouth. As your skin loses elasticity, the nasolabial folds along the nose and mouth and the marionette lines at the corners of the mouth can look more noticeable.

Refyne and Defyne are made with an advanced technology that allows for unique cross-linking of HA. The gel is formulated in a way that is customized to patients with varying needs.


Cross-linking determines each product’s level of flexibility and support. The crosslinks are like the knots that hold a net’s strands together. Since Refyne has less crosslinking, it is woven more loosely. Defyne is more tightly-woven due to greater crosslinking.

In turn, the Refyne gel has greater flexibility and moderate support while Defyne is less flexible but has greater support. Refyne softens moderate lines and Defyne lifts deeper wrinkles in patients older than 21.

Get results

FDA approval was reportedly based off of two pivotal studies, which found 79 percent and 77 percent of Refyne and Defyne subjects respectively enjoyed at least a 1-grade improvement in wrinkle severity after six weeks, with Grade 1 for “wrinkle-free” and Grade 5 for “very deep and long wrinkles.” The majority of patients saw a “meaningful improvement” in their wrinkles 12 months after treatment.

Side effects are similar to other Restylane products, including injection site redness, swelling, bruising, lumps, and discomfort for one to two weeks post-treatment. Call for your personalized consultation at Seriously Skin.

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Seriously Skin

Our name says it all~ we take the youthfulness and vitality of your skin very seriously. At Seriously Skin, our expertise is reflected in the cutting edge technology and procedures we use to achieve your end result: beautiful and healthy skin.

State of the art laser treatments, Coolsculpting, and an array of aesthetic services are only the beginning. Combined with a healthy lifestyle, we will help you turn back time on your aging skin by revealing a more youthful you.


Seriously Skin Cosmetic and Laser Medicine
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Highly recommend to anyone

"Dr. Kish is the best! She always remembers me and knows my specific needs. I would highly recommend her to anyone!"
Seriously Skin Cosmetic and Laser Medicine
Rating : 5 5 Stars

Understand my needs and works

"I feel like I am in great hands with Dr. Kish. She alleviates my fears/concerns, understand my needs and works to give me the results that I am pleased with. It keeps me coming back again and again."
Seriously Skin Cosmetic and Laser Medicine
Rating : 5 5 Stars

The staff is wonderful

"I have already started the cool sculpting getting ready for this spring n summer and I couldn't be happier!! The staff is wonderful and made me feel comfortable n relaxed. Thanks ladies I will continue to keep coming back, next I will be getting Botox!"
Seriously Skin Cosmetic and Laser Medicine
Rating : 5 5 Stars

Very happy with my results

"The doctor is very personable, I'm very happy with my results and my treatment."
Seriously Skin Cosmetic and Laser Medicine
Rating : 5 5 Stars
"The Dr. was very competent and personable."
Seriously Skin Cosmetic and Laser Medicine
Rating : 5 5 Stars

"Everyone in the office helped answer our questions. Dr. Kish is very knowledgeable and straightforward. We will definitely go back!"
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